Title of article
Design of Intelligent Polymer of Gelatin- Poly N-isopropyla- crylamide under Gamma radiation for Cellular Applications
Author/Authors
Heidari Keshel، Saeed نويسنده Proteomics Research Center, Faculty of Paramedical Sciences , , Soleimani، Bita نويسنده Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran , , Ebrahimi، Maryam نويسنده Tissue Engineering Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , , Ashrafi Hafez، Asghar نويسنده Safety promotion and injury prevention research center, Shahid Beheshti University of medical sciences, Tehran , , Fallahakbarpour، Razieh نويسنده Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran , , Khaledian، Mohammad Ali نويسنده , , Yousefi، Fatemeh نويسنده Babol University of Medical Sciences, Babol, Iran , , Rostampour Kakroudi، Maryam نويسنده Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran. , , Fathi Arateh، Forough نويسنده Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran. ,
Issue Information
دوفصلنامه با شماره پیاپی 0 سال 2013
Pages
8
From page
171
To page
178
Abstract
Thermo-sensitive polymers were prepared by graft copolymerization of gelatin with N-Isopropylacrylamide via gamma radiation. Characterization of polymers such as DSC analysis, swelling in different ratios and cell assays were investigated. DSC and solubility analysis showed gelatin and N-Isopropylacrylamide monomers were grafted via gamma radiation successfully. Results show swelling of samples increased as gelatin increased. Swelling ratio and curves results administrated hyd-ro-philicity / hydrophobicity of hydrogel that this property is due to presence of N-Isopropylacrylamide in different temperatures. The polymer was tested for harvesting epithelial cells after carrying out cell culture at 37 °C and incubating the confluent cells at 10°C for spontaneous detachment of cell sheet from polymer surface without enzyme treatment. These unique properties of the hydrogel would make it a promising support for drug delivery systems and tissue regeneration.
Journal title
Journal of Reports in Pharmaceutical Sciences
Serial Year
2013
Journal title
Journal of Reports in Pharmaceutical Sciences
Record number
1969075
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