Title of article :
Synthesis, characterization, antimicrobial and enzymatic activity of 4b,9b-dihydroxy-7,8-dihydro-4bH-indeno[1,2-b]benzofuran-9,10(6H,9bH)-dione
Author/Authors :
Mehdi، نويسنده , , Sayed Hasan and Hashim، نويسنده , , Rokiah and Ghalib، نويسنده , , Raza Murad and Fلtima C. Guedes da Silva، نويسنده , , M. and Sulaiman، نويسنده , , Othman and Rahman، نويسنده , , Syed Ziaur and Murugaiyah، نويسنده , , Vikneswaran and Marimuthu، نويسنده , , Mani Maran Ratnam، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
The crystal structure of the title compound, 4b,9b-dihydroxy-7,8-dihydro-4bH-indeno[1,2-b]benzofuran-9,10(6H,9bH)-dione has been determined by single crystal X-ray diffraction. It crystallizes in the monoclinic space group P21/c with Z = 4. The FTIR as well as the 1H and 13C NMR spectra of the compound were also recorded and briefly discussed. The compound showed potential antimicrobial activity comparable to that of clinically used antimicrobial agents against selected microorganisms. It has selective and moderate inhibitory activity on butyryl cholinesterase enzyme and could serve as potential lead compound for synthesis of more bioactive derivatives.
Keywords :
2-b]benzofuran-9 , 10(6H , Cholinesterase enzymes , 9bH)-dione , crystal structure , NMR spectra , 4b , 9b-Dihydroxy-7 , antimicrobial activity , Inter-molecular hydrogen bonding
Journal title :
Journal of Molecular Structure
Journal title :
Journal of Molecular Structure