Author/Authors :
Yoshino، نويسنده , , Norio and Nakajima، نويسنده , , Kaori and Nakamura، نويسنده , , Keisuke and Kondo، نويسنده , , Yukishige and Ohashi، نويسنده , , Katsura and Nihei، نويسنده , , Tomotaro and Saito، نويسنده , , Masahiro and Teranaka، نويسنده , , Toshio، نويسنده ,
Abstract :
Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.
Keywords :
Cell affinity , Surface modification , Silane coupling agent having amide group , Biosilane , bone formation
