Title of article :
A silver complex with tryptophan: Synthesis, structural characterization, DFT studies and antibacterial and antitumor assays in vitro
Author/Authors :
Carvalho، نويسنده , , Marcos A. and de Paiva، نويسنده , , Raphael E.F. and Bergamini، نويسنده , , Fernando R.G. and Gomes، نويسنده , , Alexandre F. and Gozzo، نويسنده , , Fلbio C. and Lustri، نويسنده , , Wilton R. and Formiga، نويسنده , , André L.B. and Shishido، نويسنده , , Silvia M. and Ferreira، نويسنده , , Carmen V. and Corbi، نويسنده , , Pedro P.، نويسنده ,
Abstract :
The synthesis, spectroscopic characterization and biological assays of a new silver(I) complex with l-tryptophan (TRP) are presented. Elemental and thermal analyses and ESI-QTOF mass spectrometric measurements of the solid compound suggest the composition AgC11H11N2O2. Infrared and solid-state NMR analyses indicate coordination of TRP to Ag(I) ion through the nitrogen of the NH2 group and also through the oxygen of carboxylate group. Theoretical (DFT) calculations permit proposing an optimized geometry for the complex. Antibacterial assays indicated that the Ag-TRP complex is effective against Staphylococcus aureus and Enterococcus faecalis (Gram-positive), and Pseudomonas aeruginosa and Escherichia coli (Gram-negative) bacterial strains. The complex was also cytotoxic against Panc-1 (human pancreatic carcinoma) and SK-Mel 103 (human melanoma) cells.
Keywords :
ESI-QTOF mass spectrometry , solid-state NMR , silver , Antitumoral assays , Antibacterial agent , L-tryptophan
