Author/Authors :
Lee، نويسنده , , Woong Ryeol and Oh، نويسنده , , Kyung Taek and Park، نويسنده , , So Young and Yoo، نويسنده , , Na Young and Ahn، نويسنده , , Yong Sik and Lee، نويسنده , , Don Haeng and Youn، نويسنده , , Yu Seok and Lee، نويسنده , , Deok-Keun and Cha، نويسنده , , Kyung-Hoi and Lee، نويسنده , , Eun Seong، نويسنده ,
Abstract :
Herein, we describe magnetic cell levitation models using conventional polymeric microparticles or nanoparticles as a substrate for the three-dimensional tumor cell culture. When the magnetic force originating from the ring-shaped magnets overcame the gravitational force, the magnetic field-levitated KB tumor cells adhered to the surface area of magnetic iron oxide (Fe3O4)-encapsulated nano/microparticles and concentrated clusters of levitated cells, ultimately developing tumor cells to tumor spheroids. These simple cell culture models may prove useful for the screening of anticancer drugs and their formulations.
Keywords :
PLLA-b-PEG-folate nanoparticle , PLGA microparticle , iron oxide , Tumor spheroid
