Author/Authors :
Yang، نويسنده , , Chao and Ma، نويسنده , , Fei and Tang، نويسنده , , Jing and Han، نويسنده , , Lina Wei-Wei Fang، نويسنده , , Shaohua and Zhou، نويسنده , , Lin and Zhou، نويسنده , , Jiahong and Shen، نويسنده , , Jian and Ge، نويسنده , , Xuefeng، نويسنده ,
Abstract :
Interaction studies of the vanadyl-hypocrellin A (VO2+-HA) complex and hypocrellin A (HA) with CT DNA were investigated by UV–Vis spectroscopy, DNA melting, fluorescence spectra and zeta potential measurements. The binding constants and binding mechanisms of HA and VO2+-HA with CT DNA had also been studied by fluorescence quenching experiments. Both spectrophotometric and DNA melting studies indicated that VO2+-HA and HA could bind to CT DNA. Thermodynamic parameters together with zeta potential studies revealed that the binding force between HA or VO2+-HA with CT DNA was hydrophobic and electrostatic force, separately.
Keywords :
VO2+-HA complex , Fluorescence spectroscopy , zeta potential , UV-spectroscopy , CT DNA , HA
