Title of article :
Electrochemical enantioselective recognition of tryptophane enantiomers based on chiral ligand exchange
Author/Authors :
Chen، نويسنده , , Qiao and Zhou، نويسنده , , Juan and Han، نويسنده , , Qian and Wang، نويسنده , , Yonghua and Fu، نويسنده , , Yingzi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
6
From page :
130
To page :
135
Abstract :
Electrochemical enantioselective recognition of tryptophane (Trp) enantiomers in the presence of Cu(II) using l-cysteine (l-Cys) self-assembled gold electrode is described. The chiral recognition of Trp enantiomers was investigated via cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and quartz crystal microbalance (QCM). Time dependencies of the enantioselective interaction for the l-Cys modified electrodes with Trp enantiomers solutions in the presence of Cu(II) were also studied. The results showed that l-Cys had stronger interaction with d-Trp than l-Trp in the presence of Cu(II), and the discrimination was caused by the selective formation of Cu complexes with l-Cys and Trp enantiomers relying on the principle of chiral ligand exchange. The structure of the Cu complexes was optimized by the hybrid density functional theory (DFT) method. And the enantiomeric composition of l- and d-Trp was monitored by measuring the current responses of the sample.
Keywords :
Enantioselectivity recognition , Tryptophane enantiomers , copper ions , Chiral ligand exchange , l-Cysteine modified gold electrode
Journal title :
Colloids and Surfaces B Biointerfaces
Serial Year :
2012
Journal title :
Colloids and Surfaces B Biointerfaces
Record number :
1974377
Link To Document :
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