Title of article :
Synthesis, characterization and cholinesterase enzymes inhibitory activity of 1-[3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-4,5-dihydro-pyrazol-1-yl]-ethanone
Author/Authors :
Mehdi، نويسنده , , Sayed Hasan and Ghalib، نويسنده , , Raza Murad and Hashim، نويسنده , , Rokiah and da Silva، نويسنده , , M. Fلtima C. Guedes and Sulaiman، نويسنده , , Othman and Murugaiyah، نويسنده , , Vikneswaran and Marimuthu، نويسنده , , Mani Maran and Naqvi، نويسنده , , Mehnaz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
The crystal structure of the title compound, 1-[3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-4,5-dihydro-pyrazol-1-yl]-ethanone has been determined by single crystal X-ray diffraction. It crystallizes in the orthorhombic space group P212121. The FTIR as well as the 1H and 13C NMR spectra of the compound were also recorded and briefly discussed. Compound 1 demonstrated good inhibitory activity against butyrylcholinesterase (BChE; IC50 = 46.42 μM) comparable to physostigmine. However it showed moderate inhibitory activity against acetylcholinesterase (AChE; IC50 = 157.31 μM). It showed moderate inhibitory activity against acetylcholinesterase and selective inhibitory activity towards butyrylcholinesterase enzyme.
Keywords :
NMR spectra , Acetylcholinesterase , Butyrylcholinesterase , 1-H , 6 , 5-dihydro-pyrazol-1-yl]-ethanone , crystal structure , Inter-molecular hydrogen bonding , 6-trimethyl-cyclohex-1-enyl)-4
Journal title :
Journal of Molecular Structure
Journal title :
Journal of Molecular Structure
