Title of article
Stereospecific ligands and their complexes. Part XII. Synthesis, characterization and in vitro antiproliferative activity of platinum(IV) complexes with some O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid against colon cancer (HCT-1
Author/Authors
Stojkovi?، نويسنده , , Danijela Lj. and Jevti?، نويسنده , , Verica V. and Radi?، نويسنده , , Gordana P. and ?a?i?، نويسنده , , Dragana S. and ?ur?i?، نويسنده , , Milena G. and Markovi?، نويسنده , , Sne?ana D. and ?inovi?، نويسنده , , Vesna M. and Petrovi?، نويسنده , , Vladimir P. and Trifunovi?، نويسنده , , Sre?ko R.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
8
From page
21
To page
28
Abstract
Synthesis of three new platinum(IV) complexes C1–C3, with bidentate N,N′-ligand precursors, O,O′-dialkyl esters (alkyl = propyl, butyl and pentyl), of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid, H2-S,S-eddp were reported. The reported platinum(IV) complexes characterized by elemental analysis and their structures were discussed on the bases of their infrared, 1H and 13C NMR spectroscopy. In vitro antiproliferative activity was determined on tumor cell lines: human colon carcinoma HCT-116 and human breast carcinoma MDA-MB-231, using MTT test.
Keywords
Antiproliferative activity , MTT test , Platinum(IV) complexes , apoptosis , HCT-116 cells , MDA-MB-231 cells
Journal title
Journal of Molecular Structure
Serial Year
2014
Journal title
Journal of Molecular Structure
Record number
1975670
Link To Document