Author/Authors :
Zhi، نويسنده , , Defu and Zhang، نويسنده , , Shubiao and Qureshi، نويسنده , , Farooq and Zhao، نويسنده , , Yinan and Cui، نويسنده , , Shaohui and Wang، نويسنده , , Bing and Chen، نويسنده , , Huiying and Yang، نويسنده , , Baoling and Zhao، نويسنده , , Defeng، نويسنده ,
Abstract :
A novel series of carbamate-linked cationic lipids containing hydroxyl headgroup were synthesized and included in formulations for transfection assays. The DNA–lipid complexes were characterized for their ability to bind DNA, their size, ζ-potential and cytotoxicity. Compared with our previously reported cationic transfection lipid DDCDMA lacking the hydroxyl group and the commercially available, these cationic liposomes exhibited relatively higher transfection efficiency.
Keywords :
Carbamate-linked cationic lipids , Hydroxyl group , Transfection efficiency , gene delivery , cytotoxicity
