Title of article :
Effect of choline carboxylate ionic liquids on biological membranes
Author/Authors :
Rengstl، نويسنده , , Doris and Kraus، نويسنده , , Birgit and Van Vorst، نويسنده , , Matthew and Elliott، نويسنده , , Gloria D. and Kunz، نويسنده , , Werner، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
Choline carboxylates, ChCm, with m = 2–10 and choline oleate are known as biocompatible substances, yet their influence on biological membranes is not well-known, and the effect on human skin has not previously been investigated. The short chain choline carboxylates ChCm with m = 2, 4, 6 act as hydrotropes, solubilizing hydrophobic compounds in aqueous solution, while the longer chain choline carboxylates ChCm with m = 8, 10 and oleate are able to form micelles.
present study, the cytotoxicity of choline carboxylates was tested using HeLa and SK-MEL-28 cells. The influence of these substances on liposomes prepared from dipalmitoylphosphatidylcholine (DPPC) was also evaluated to provide insights on membrane interactions. It was observed that the choline carboxylates with a chain length of m > 8 distinctly influence the bilayer, while the shorter ones had minimal interaction with the liposomes.
Keywords :
biological membrane , Choline ionic liquids , cytotoxicity
Journal title :
Colloids and Surfaces B Biointerfaces
Journal title :
Colloids and Surfaces B Biointerfaces