Ammonium carbonate: As a dual source reagent

Cong liu and et.al described an efficient and convenient method for the one-pot synthesis 2-alkyl-4(5)-aryl-1H-imidazoles by using cyclocondensation from ?-bromo aryl methyl ketones, aliphatic carboxylic acids and ammonium carbonate without using any catalyst. Firstly the organic acids and ammonium carbonate produced organic amides at high temperature, then the amide reacted with added 2-bromo-1-phenylethanone to give corresponding imidazole. Imidazole moieties has been used as core center for the synthesis of ionic liquids, anti-nociceptive agents, anti-hypertensive drugs and so on.