Author/Authors :
Mittler، نويسنده , , Ron and Vanderauwera، نويسنده , , I-Yin Sandy and Suzuki، نويسنده , , Nobuhiro and Miller، نويسنده , , Gad and Tognetti، نويسنده , , Vanesa B. and Vandepoele، نويسنده , , Klaas and Gollery، نويسنده , , Marty and Shulaev، نويسنده , , Vladimir and Van Breusegem، نويسنده , , Frank، نويسنده ,
Abstract :
Reactive oxygen species (ROS) play a multitude of signaling roles in different organisms from bacteria to mammalian cells. They were initially thought to be toxic byproducts of aerobic metabolism, but have now been acknowledged as central players in the complex signaling network of cells. In this review, we will attempt to address several key questions related to the use of ROS as signaling molecules in cells, including the dynamics and specificity of ROS signaling, networking of ROS with other signaling pathways, ROS signaling within and across different cells, ROS waves and the evolution of the ROS gene network.
