Title of article :
Ultrasonic-assisted synthesis of chrysin derivatives linked with 1,2,3-triazoles by 1,3-dipolar cycloaddition reaction
Author/Authors :
Jiang، نويسنده , , Yuqin and Chen، نويسنده , , Xiaolan and Qu، نويسنده , , Lingbo and Wang، نويسنده , , Junliang and Yuan، نويسنده , , Jinwei and Chen، نويسنده , , Senshen and Li، نويسنده , , Xu-Dong Qu، نويسنده , , Chen، نويسنده ,
Abstract :
The 1,3-dipolar cycloaddition reaction between 7-(3-azidopropoxy)-5-hydroxyflavone and phenylacetylene was carried out to investigate the synthesis of 7-(3-(4-phenyl-1,2,3-triazol-1-yl)propoxy)- 5-hydroxyflavone in presence of ultrasound (sono-synthesis) and absence of ultrasound (conventional method) under relatively optimized solvent and catalyst conditions. The reaction rate was notably accelerated with the help of ultrasound irradiation. An experiment was especially carried out for investigating the acceleration mechanism of ultrasound on the cycloaddition. A novel series of chrysin derivatives linked with 1,2,3-triazoles were obtained by the copper(I)-catalyzed 1,3-dipolar Huisgen cycloaddition reaction using t-BuOH/H2O (1:1 v/v) as reaction solvents and CuSO4·5H2O/sodium ascorbate as the catalyst at room temperature in the presence of ultrasound irradiation. Their structures are elucidated by NMR, ESI MS, IR and Elemental analysis.
Keywords :
Chrysin , 1 , 2 , 1 , 3-Triazole , 3-Dipolar Huisgen cycloaddition , Ultrasound
Journal title :
Astroparticle Physics