Author/Authors :
Bretanha، نويسنده , , Lizandra C. and Teixeira، نويسنده , , Vinicius E. and Ritter، نويسنده , , Marina and Siqueira، نويسنده , , Geonir M. and Cunico، نويسنده , , Wilson and Pereira، نويسنده , , Claudio M.P. and Freitag، نويسنده , , Rogério A.، نويسنده ,
Abstract :
The alternative synthesis of 12 1,2,4-oxadiazoles using ultrasound irradiation from trichloroacetoamidoxime and acyl chlorides is reported. Seven of them are novel compounds. The 3-trichloromethyl-5alkyl(aryl)-1,2,4-oxadiazoles have been synthesised in better yields and shorter reaction times compared to the conventional method. This protocol can be applicable for preparation of 1,2,4-oxadiazoles containing aryl or alkyl groups attached at their C-5 side-chain.
Keywords :
Ultrasonic irradiation , 1 , 2 , 4-oxadiazoles , Heterocycles
