Author/Authors :
Ruiz، نويسنده , , Enrique and Rodrيguez-Lَpez، نويسنده , , Hortensia and Coro، نويسنده , , Julieta and Niebla، نويسنده , , Vladimir and Rodrيguez، نويسنده , , Alfredo and Martيnez-Alvarez، نويسنده , , Roberto and de Armas، نويسنده , , Hector Novoa and Suلrez، نويسنده , , Margarita and Martيn، نويسنده , , Nazario، نويسنده ,
Abstract :
A facile, efficient and environment-friendly protocol for the synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives has been developed by the convenient ultrasound-mediated reaction of 2(1H)pyridone derivatives with the Vilsmeier–Haack reagent. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.
Keywords :
Sonochemistry , Ultrasound irradiation , 1 , 4-Dihydropyridine Derivatives , Vilsmeier–Haack reaction
