Title of article
Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin
Author/Authors
-، - نويسنده Laboratory of Toxicology and Environmental Health, Interfaculty Center of Formation and Research in Environment for the Sustainable Development, University of Abomey-Calavi (UAC), 01 PO Box 1463 Cotonou, Benin Dougnon, Tamègnon Victorien , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Bankolé, Honoré Sourou , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Klotoé, Jean Robert , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Sènou, Maximin , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Fah, Lauris , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Koudokpon, Hornel , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Akpovi, Casimir , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Dougnon, Tossou Jacques , -، - نويسنده Department of Animal Experimentation, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, PO Box LG 581 Legon, Ghana Addo, Phyllis , -، - نويسنده Laboratory of Research in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 PO Box 2009 Cotonou, Benin Loko, Frédéric , -، - نويسنده Laboratory of Toxicology and Environmental Health, Interfaculty Center of Formation and Research in Environment for the Sustainable Development, University of Abomey-Calavi (UAC), 01 PO Box 1463 Cotonou, Benin Boko, Michel
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2014
Pages
10
From page
160
To page
169
Abstract
-
Abstract
Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 400 and 800 mg/kg of body weight. Atorvastatin was used as reference treatment drug. The data were analyzed by the Brown-Forsythe ANOVA, Dunnett’s T3 multiple comparison test, and Dunnett’s t test. All tests were done at the 5% significance level. Results: Administration of S. macrocarpon (fruits as well as leaves) resulted in a statistically significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglycerides in the treated groups compared with the untreated hypercholesterolemic group, regardless of the administrated doses. A significant increase in HDL-cholesterol was observed in the treated groups. Hepatic disorders due to the Triton have been corrected by S. macrocarpon. Conclusions: This vegetable effectively suppresses experimental hypercholesterolemia in Wistar rats, suggesting a protective role in cardiovascular diseases. Its use by individuals at risk should be promoted.
Journal title
Avicenna Journal of Phytomedicine AJP)
Serial Year
2014
Journal title
Avicenna Journal of Phytomedicine AJP)
Record number
2011363
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