Author/Authors :
-، - نويسنده DM College of Pharmacy, Bahadurgah, Haryana, India. Bhatia, Saurabh , -، - نويسنده Deptt. of Pharmaceutical Sciences, Jamia Hamdard, New Delhi, India. Sharma, Kiran , -، - نويسنده Seoul National University, Republic of Korea, Korea. Sharma, Ajay , -، - نويسنده Division of Pharmaceutics, Faculty of Medical Sciences, Lovely Professional University, Phagwara, Punjab India. Nagpal, Kalpana , -، - نويسنده Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Bers, Tanmoy
Abstract :
Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Materials and Methods: Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer. Results: Among the fractions POR showed better activity. POR and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test POR significantly (p < 0.05) reduced abdominal writhes than PE. In hot plate method POR showed better analgesic activity than PE. POR showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE. Conclusions: The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions.
