Author/Authors :
Hajizadeh، Niloofar نويسنده Associated Profesor of Pediatric Nephrology, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. , , Marashi، Sayed Mahdi نويسنده Department of Forensic Medicine, School of Medicine, Tehran University of Medical , , Navabizadeh، Behnam نويسنده Pediatric Urology Research Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. , , Elhami، Ehsan نويسنده Resident of Ophthalmology, Khatam-al-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. , , Mohammadi، Tayebeh نويسنده Resident of Pediatrics, Department of Pediatrics, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. , , Mazloomi Nobandegani، Narges نويسنده Resident of Pediatrics, Department of Pediatrics, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. , , Kazemi، Naheid نويسنده Resident of Pediatrics, Children’s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Science, Tehran, Iran. , , Navabizadeh، Raheleh نويسنده Resident of Pediatrics, Children’s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Science, Tehran, Iran. ,
Abstract :
Introduction
In children with Nephrotic Syndrome (NS), it is probable to determine a hypothyroid state because of Thyroxine (T4), Triiodothyronine (T3) and Thyroid-binding globulin loss in presence of proteinuria. The aim of this study was to examine thyroid function in pediatric cases of nephrotic syndrome.
Materials and Methods
In a cross-sectional study, from march 2010 to march 2012, thyroid function tests were performed in 104 patients referred to the Nephrology Department of Children’s Medical Center, Tehran-Iran; because of nephrotic syndrome. Collected data analyzed with SPSS 17 software and p < 0.05 used to denote statistical significance.
Results
Sixty one cases identified as hypothyroid patients and were treated with supplementary levothyroxine. There were 41 (67.2%) males and 20 (32.8%) females with the mean age of 3.72±3.35 years. Our patients showed lowered T3 (68.3%) and T4 (64.4%) in comparison with normal values. Median Thyroid-stimulating hormone (TSH) was 11.65±6.71 Micu/ml and 2.82±0.82 in the hypothyroid and euthyroid patients respectively. In all, TSH was negatively correlated with the total urinary protein content.
Conclusions
According to this study, the occurrence of hypothyroidism in any child with nephrotic syndrome needs to be mentioned. It is proposed to systematically search hypothyroidism by measuring TSH and free T4 in these patients particularly when proteinuria is prolonged.
