Author/Authors :
Mikado، نويسنده , , S. and Yanagie، نويسنده , , H. Y. Yasuda، نويسنده , , Azusa N. and Higashi، نويسنده , , S. and Ikushima، نويسنده , , I. and Mizumachi، نويسنده , , Joshua R. and Murata، نويسنده , , Y. and Morishita، نويسنده , , Y. and Nishimura، نويسنده , , Peter R. and Shinohara، نويسنده , , A. and Ogura، نويسنده , , K. and Sugiyama، نويسنده , , H. and Iikura، نويسنده , , H. and Ando، نويسنده , , H. and Ishimoto، نويسنده , , M. and Takamoto، نويسنده , , S. and Eriguchi، نويسنده , , M. and Takahashi، نويسنده , , H. and Kimura، نويسنده , , M.، نويسنده ,
Abstract :
It is necessary to accumulate the 10B atoms selectively to the tumor cells for effective Boron Neutron Capture Therapy (BNCT). In order to achieve an accurate measurement of 10B accumulations in the biological samples, we employed a technique of neutron capture autoradiography (NCAR) of sliced samples of tumor tissues using CR-39 plastic track detectors. The CR-39 track detectors attached with the biological samples were exposed to thermal neutrons in the thermal column of the JRR3 of Japan Atomic Energy Agency (JAEA). We obtained quantitative NCAR images of the samples for VX-2 tumor in rabbit liver after injection of 10BSH entrapped water-in-oil-in-water (WOW) emulsion by intra-arterial injection via proper hepatic artery. The 10B accumulations and distributions in VX-2 tumor and normal liver of rabbit were investigated by means of alpha-track density measurements. In this study, we showed the selective accumulation of 10B atoms in the VX-2 tumor by intra-arterial injection of 10B entrapped WOW emulsion until 3 days after injection by using digitized NCAR images (i.e. alpha-track mapping).
Keywords :
CR-39 , boron neutron capture therapy (BNCT) , WOW emulsion , Neutron capture autoradiography (NCAR) , Boron Delivery System
