Author/Authors :
Dilmanian، نويسنده , , F.A. and Qu، نويسنده , , Y. and Liu، نويسنده , , S. M. Cool، نويسنده , , C.D. and Gilbert، نويسنده , , J. and Hainfeld، نويسنده , , J.F. and Kruse، نويسنده , , C.A. and Laterra، نويسنده , , J. and Lenihan، نويسنده , , D. and Nawrocky، نويسنده , , M.M. and Pappas، نويسنده , , G. and Sze، نويسنده , , C.-I. and Yuasa، نويسنده , , Margaret T. and Zhong، نويسنده , , N. and Zhong، نويسنده , , Z. and McDonald، نويسنده , , J.W.، نويسنده ,
Abstract :
Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissueʹs microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.
