Analytical reconstruction of 4-D dynamic cardiac SPECT with noise-reduction and non-uniform attenuation compensation

Background tudy focuses on quantitative reconstruction of dynamic cardiac SPECT. al and methods rhunen–Loeve (KL) transform is first applied to gated frames or sinogram data to de-correlate the dynamic information along the time direction. Then the Poisson noise is treated by a penalized weighted least-squares minimization, followed by an analytical inversion of the treated sinograms with attenuation compensation via the Novikov formula. The reconstruction is completed by inverse KL transform. s c or gated cardiac sinograms were simulated from the NCAT phantom mimicking the human torso, and their reconstructions by the presented method showed significant improvement over the conventional methods of frame-by-frame reconstruction. sion nalytical reconstruction of dynamic SPECT is consistent and efficient with a good potential for practical use.