Author/Authors :
Falahzadeh، Khadijeh نويسنده Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Banaei-Esfahani، Amir نويسنده Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran , , Shahhoseini، Maryam نويسنده Department of Genetics, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran ,
Abstract :
Over the past few decades, actin’s presence in the nucleus has been demonstrated. Actin
is a key protein necessary for different nuclear processes. Although actin is well known for
its functional role in dynamic behavior of the cytoskeleton, emerging studies are now highlighting
new roles for actin. At the present time there is no doubt about the presence of actin
in the nucleus. A number of studies have uncovered the functional involvement of actin
in nuclear processes. Actin as one of the nuclear components has its own structured and
functional rules, such as nuclear matrix association, chromatin remodeling, transcription
by RNA polymerases I, II, III and mRNA processing. In this historical review, we attempt to
provide an overview of our current understanding of the functions of actin in the nucleus.
