Protective Role of Alkaloid Compound Isolated from Hapalosiphon aureus against Paracetamol Induced Hepatotoxicity in Male Rats

The present study investigated the effect of alkaloid compound isolated from Hapalosiphon aureus against paracetamol induced toxicity in male rats. Twenty four white male rats were used, these animals were divided into four groups each group contain six animals as a following: the first group I is the control group treated with(1 ml/kg) of normal saline for two weeks, the second group (II) treated with (1 ml/kg) of alkaloid compound isolated from Hapalosiphon aureus for two week, the third group III treated (I.P.) with paracetamol (1 ml/ kg) at the first day and fourth day of the first week , the fourth group IV treated (I.P.) with paracetamol (1 ml/ kg ) at the first day and the fourth day of the first week , and then treated orally with Hapalosiphon aureus for one week of the fourth group . The result indicate that the paracetamol caused a significant increased (p < 0.05) in the level of the serum alanin transferase (ALT), aspartate transferase (AST), cholesterol, and triglyceride levels in the third group comparison with control group. Also, there was a significant decreased in albumin. Protective activity of alkaloid compound isolated from Hapalosiphon aureus against toxicity of paracetamol observed in decreasing of ALT, AST, cholesterol, and triglyceride levels, and increased in the albumin levels in the fourth group comparison with third group.