Title of article :
Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer
Author/Authors :
Garibaldi، نويسنده , , F. and Cisbani، نويسنده , , E. and Colilli، نويسنده , , S. and Cusanno، نويسنده , , F. and Fratoni، نويسنده , , R. and Giuliani، نويسنده , , F. and Gricia، نويسنده , , M. and Lucentini، نويسنده , , M. and Fratoni، نويسنده , , R. and Lo Meo، نويسنده , , S. and Magliozzi، نويسنده , , M.L. and Santanvenere، نويسنده , , F. and Cinti، نويسنده , , M.N. and Pani، نويسنده , , R. De Pellegrini، نويسنده , , R. and Simonetti، نويسنده , , G. and Schillaci، نويسنده , , O. and Del Vecchio، نويسنده , , S. and Salvatore، نويسنده , , M. and Majewski، نويسنده , , Robson S. and Lanza، نويسنده , , R.C. and De Vincentis، نويسنده , , G. and Scopinaro، نويسنده , , F.، نويسنده ,
Pages :
5
From page :
286
To page :
290
Abstract :
Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(Tl)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6×6 mm2 and 3×3 mm2). Detectors having a field of view (FOV) of 100×100 mm2 and 150×200 mm2 were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented.
Keywords :
breast cancer , Radionuclides , High-resolution molecular imaging
Journal title :
Astroparticle Physics
Record number :
2030557
Link To Document :
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