Title of article
Expression of melanocortin-4 receptor and agouti-related peptide mRNAs in arcuate nucleus during long term malnutrition of female ovariectomized rats
Author/Authors
-، - نويسنده Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Sarvestani, Fatemeh Sabet , -، - نويسنده Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Transgenic Te.chnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Tamadon, Amin , -، - نويسنده Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Hematzadeh, Aida , -، - نويسنده Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Jahanara, Maliheh , -، - نويسنده Department of Animal Sciences, College of Agriculture, Shiraz University, Shiraz, Iran Jafarzadeh Shirazi, Mohammad Reza , -، - نويسنده Biotechnology Institute, College of Agriculture, Shiraz University, Shiraz, Iran Moghadam, Ali , -، - نويسنده Biotechnology Institute, College of Agriculture, Shiraz University, Shiraz, Iran Niazi, Ali , -، - نويسنده Department of Stem Cells and Developmental Biology at the Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Moghiminasr, Reza
Issue Information
فصلنامه با شماره پیاپی 0 سال 2015
Pages
4
From page
104
To page
107
Abstract
-
Abstract
Objective: Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. Materials and Methods: Ten female ovariectomized rats were divided into two equal groups (n=6) of normal and restricted diet groups. Using real-time PCR, the relative expressions (compared to controls) of MC4R and AgRP mRNAs were compared between both diet groups. Results: The relative expression of MC4R and AgRP mRNA in the ARC of female ovariectomized rats during long term malnutrition was higher than those with normal diet (P<0.05). Conclusion: Changes in the relative expression level of MC4R and AgRP mRNAs during long term malnutrition of rat indicated a stimulatory role of MC4R and AgRP in regulating energy balance in ARC of rat hypothalamus.
Journal title
Iranian Journal of Basic Medical Sciences
Serial Year
2015
Journal title
Iranian Journal of Basic Medical Sciences
Record number
2037027
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