Potential agents to control enamel caries-like lesions

Objectives ess whether pastes containing casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) and calcium sodium phosphosilicate (CSP) control artificial caries lesion progression. s slabs of bovine teeth were embedded in polyester resin and had their enamel surfaces serially polished, and tested for surface microhardness (SMH, 25 g, 5 s). Incipient caries-like lesions were pre-formed and specimens were evaluated by microhardness test (SMHpost-lesion) and randomly assigned to five treatment groups (n = 15): (1) regular dentifrice (RE, 1,100 ppm F); (2) dentifrice with calcium sodium phosphosilicate (CSP); (3) amorphous calcium phosphate stabilized by casein phosphopeptide (CPP–ACP); (4) CPP–ACP with 900 ppm F (CPP–ACP + F) and (5) control group—unexposed to any remineralizing agent. Treatments were applied five times, after the de-remineralization period in the cariogenic challenges. Post-treatments SMH measurements were conducted (SMHpost-treatment). s was applied for data evaluation and revealed a significant difference among the treatments (p = 0.0161). Tukeyʹs test was conducted and the percentage of mineral loss was calculated. Specimens exposed to CSP (7.1%), RE (6.7%) and CPP–ACP + F (3.8%) showed lower mineral loss than those that in the control group (−11.0%). CPP–ACP group (3.2%) differed from the control, CSP and RE groups. sions ing on the agent used, a remineralizing effect may be expected, which reflects in caries lesions progression.