Author/Authors :
Bozzini، Giorgio نويسنده Academic Department of Urology, Istituto Di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, University of Milan, Milan, Italy. , , Rubino، Barbara نويسنده Pathology Unit, Istituto Di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, University of Milan, Milan, Italy , , Maruccia، Serena نويسنده Academic Department of Urology, Istituto Di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, University of Milan, Milan, Italy. , , Marenghi، Carlo نويسنده Academic Department of Urology, Istituto Di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, University of Milan, Milan, Italy , , Casellato، Stefano نويسنده Academic Department of Urology, Istituto Di Ricovero e Cura a Carattere Scientifico, Policlinico San Donato, University of Milan, Milan, Italy. , , Picozzi، Stefano نويسنده Urology Department, IRCCS Policlinico San Donato , , Carmignani، Luca نويسنده Urology Department, IRCCS Policlinico San Donato ,
Abstract :
Purpose: To assess the validity of frozen section examination (FSE) on testis nodules.
Materials and Methods: A series of 86 preselected patients with testicular nodules were recruited
in this study. Nodules smaller than 2 cm had been surgically removed and biopsies of
the margins performed. Larger nodules were just biopsied. Orchiectomy was the treatment of
choice for malignant lesions and stromal tumors. Conservative surgery was performed on 2
previously monorchid patients with Leydig cell tumor because of the presence of just one testis.
Conservative surgery was the treatment of choice for benign lesions in 32 cases.
Results: At FSE we observed that nodules were malignant germinal tumors in 47% of the
cases, stromal tumors in 7% of the cases, benign lesions in 45% of the cases and doubtful
for lymphoproliferative lesion in 1 case. The diagnosis made by FSE were confirmed in the
definitive ones in all of them, we reported just 2 cases of Leydig cell tumor and benign fibrosis
lesion. In these 2 cases, definitive histology of the collected specimens revealed areas of
Leydig cell hyperplasia and seminomatous foci, respectively.
Conclusion: Our data suggest that FSE is a valid tool to discriminate between benign and
malignant neoplastic lesions, particularly when an adequate sample is available
