Chiral discrimination of basic and hydrophobic molecules by chemical force spectroscopy

Chemical force spectroscopy (CFS) is becoming a powerful technique with which to measure intermolecular forces. The prime advantage over other techniques is the ability to map spatial distribution of ligands on the surface. We have used CFS to explore the binding force of a variety of different chiral molecules in order to understand more about the nature of what is a fundamental aspect of chemical biology and of central importance in pharmacology.