Author/Authors :
Sahmani، Mehdi نويسنده Department of Clinical Biochemistry and Genetics, Cellular and Molecular Research Centre , , Darabi، Masoud نويسنده Department of Biochemistry and Clinical Laboratories, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Darabi، Maryam نويسنده Department of Biochemistry and Genetics, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , , Dabaghi، Talaat نويسنده Kosar Hospital, Qazvin, Iran , , Alizadeh، Safar Ali نويسنده Department of Clinical Biochemistry and Medical Genetics, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran , , Najafipour، Reza نويسنده Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran ,
Abstract :
Background: Endometriosis is a chronic gynecological disease resulting from complex
interactions between genetic, hormonal, environmental and oxidative stress and intrinsic
inflammatory components. The aim of this study was to investigate the potential association
of the 763C > G polymorphism in the secretory phospholipase A2 group IIa gene
(PLA2G2A) with the risk of endometriosis in Iranian women.
Materials and Methods: Ninety seven patients with endometriosis along with 107 women
who were negative for endometriosis after laparoscopy and laparatomy, and served as
the control group, were enrolled for this cross-sectional study. Samples were genotyped
using the polymerase chain reaction-restriction fragment length polymorphism method.
Results: Multivariate analysis was used to examine the association between the risk of endometriosis
and the 763C > G polymorphism of PLA2G2A. Genotype distributions of PLA-
2G2A were significantly different between patients and the controls (p < 0.001, OR=0.22, 95%
CI=0.21-0.39). Correlation analysis showed that there was a significant association between
the normal homozygous genotype and susceptibility to endometriosis (p < 0.001).
Conclusion: The present study suggests that the 763C > G polymorphism of PLA2G2A plays
an important role as an independent factor in the risk of endometriosis in Iranian women.
