Author/Authors :
Juan C. Begara-Morales، نويسنده , , Isabel and Lujan، نويسنده , , Luis and Hopkins، نويسنده , , John and Collie، نويسنده , , David D.S. and Miller، نويسنده , , Hugh R.P. and Watt، نويسنده , , Neil J.، نويسنده ,
Abstract :
The stage of activation of bronchoalveolar lavage fluid (BALF) lymphocytes and peripheral blood lymphocytes (PBL) from maedi-visna virus (MVV) infected (n= 7) and control (n= 7) sheep was investigated by assessing four parameters of lymphocyte activation; lymphocyte size and complexity, loss of CD5+ T cells, expression of cell surface interleukin-2 receptor (IL-2R) and expression of DR and DQ MHC Class II molecules. BALF lymphocytes from MVV-infected animals had a significant loss of CD5+ lymphocytes (P<0.05) and upregulation of DR and DQ MHC Class II molecules compared with controls, consistent with BALF lymphocyte activation. No changes in cell size and complexity or expression of IL-2R were observed. No evidence of PBL activation was detected. These findings suggest an impaired BALF lymphocyte activation during MVV infection.
