Title of article :
Reactivity of workshop antibodies with a non-ruminant species: Crossreactivity with canine blood leukocytes
Author/Authors :
Schuberth، نويسنده , , H.-Joachim and Beer، نويسنده , , Anja and Rabe، نويسنده , , H.-Udo and Leibold، نويسنده , , Wolfgang، نويسنده ,
Abstract :
Three-hundred and eight monoclonal antibodies detecting surface determinants on ruminant cells were tested on canine leukocytes by flow cytometry. Thirty mabs showed crossreactivity: 25 of them reacted uniformly with cells of three unrelated dogs, five displayed a polymorphic reaction pattern. Thus, in addition to mabs with yet unknown specificity, antibodies to ruminant WC9, B-cell antigens and possible CD29, CD49d cross-react with canine cells, and probably react with the homologous canine antigen.
Keywords :
CD molecules , crossreactivity , Monoclonal antibodies , dog
Journal title :
Astroparticle Physics
