Author/Authors :
Pinheiro، نويسنده , , Syed A.M. and Costa، نويسنده , , S.L. and Freire، نويسنده , , S.M. and Almeida، نويسنده , , M.A.O. and Tardy، نويسنده , , M. and El Bachل، نويسنده , , R. and Costa، نويسنده , , M.F.D.، نويسنده ,
Abstract :
The protozoan Neospora caninum has a veterinary importance because it causes abortion in cattle and neuromuscular alterations in dogs. We infected rat astrocytes, in vitro, with different concentrations of N. caninum. Astrocytes responded to infection by producing the pro-inflammatory cytokine TNF-α and the neurotoxic—free radical NO, 24 and 72 h post-infection. These data suggest that astrocytes, which are essential for brain function, are targets for the parasite and this represents a practical and valid model to study the effects of N. caninum on the CNS.
Keywords :
Neospora caninum , astrocytes , model , Infection , TNF-? and NO
