Title of article
CCH cells are potent stimulators in the allogeneic mixed leucocyte reaction
Author/Authors
Baines، نويسنده , , S.J. and Blacklaws، نويسنده , , B.A. and McInnes، نويسنده , , E. and McConnell، نويسنده , , I.M.، نويسنده ,
Pages
6
From page
316
To page
321
Abstract
Canine cutaneous histiocytoma (CCH) has been identified as a tumour of epidermal Langerhans cells (LCs) on the basis of immunophenotypic studies. Neoplastic Langerhans cells (CCH-LCs) were isolated from lesions of canine cutaneous histiocytoma. The CCH-LC cells expressed CD1b, CD11/18, CD45, MHC-I, and MHC-II. The CCH-LC cells were potent stimulators of the mixed leucocyte reaction (MLR) in vitro when compared to PBMCs from the tumour-bearing animals. This provides evidence that the neoplastic cells in CCH have functional as well as immunophenotypic characteristics of Langerhans cells.
Keywords
MLR , dendritic cell , canine , Langerhans cell , Cutaneous histiocytoma
Journal title
Astroparticle Physics
Record number
2056768
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