Author/Authors :
Lee، Won Ki نويسنده Department of Urology, College of Medicine, Hallym University, Chun Cheon, Korea , , Lee، Sang Eun نويسنده Department of Urology, College of Medicine, Seoul National University, Seoul, Korea. , , Hong، Sung Kyu نويسنده Department of Urology, College of Medicine, Seoul National University, Seoul, Korea. , , Jeong، Chang Joon نويسنده , , Park، Yong Hyun نويسنده Department of Urology, College of Medicine, Seoul National University, Seoul, Korea. , , Kang، Seok Ho نويسنده Department of Urology, College of Medicine, Korea University, Seoul, Korea. , , Kim، Yong-June نويسنده Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea. , , Hong، Sung-Hoo نويسنده Department of Urology, College of Medicine, Catholic University, Seoul, Korea. , , Choi، Won Suk نويسنده Department of Urology, Choi Won Suk Urology Clinic, Yongin, Korea. , , Byun، Seok-Soo نويسنده 2Department of Urology, College of Medicine, Seoul National University, Seoul, Korea. ,
Abstract :
Purpose: To analyze the characteristics of nonmetastatic papillary renal cell carcinomas (RCC) and the prognostic value of RCC histologic subtyping, based on a large multicenter experience in Korea.
Materials and Methods: A total of 2,905 patients with nonmetastatic RCC (TxN0M0) at the time of surgery were retrospectively enrolled from five institutions between 1999 and 2011 in Korea. Among these, patients with clear cell subtype (n = 2,488, 85.6%) and papillary subtype (n = 192, 6.6%) were included in our study.
Results: Patients with papillary subtype did not differ significantly from those with clear cell subtype on the following parameters: age (P = .694), gender (P = .511), body mass index (P = .136), patient performance status (P = .419), symptoms at presentation (P = .419), tumor size (P = .778) and pathologic stage (P = .367). However, high Fuhrman’s grades were more common in papillary subtypes compared with clear cell subtypes (P = .001). The 5-year recurrence-free survival rates in patients with clear cell subtype and papillary subtype were 84.9% and 86.7%, respectively (P = .167). The 5-year cancer-specific survival rates in patients with clear cell subtype and papillary subtype were 92.0% and 93.1%, respectively (P = .931). Histologic subtype was not an independent prognostic factor of recurrence-free and cancer-specific survival (P = .107 and P = .998, respectively).
Conclusion: Our study suggests that the characteristics and prognosis of papillary subtype might be comparable to those of clear cell subtype in non-metastatic RCC, especially in Asia
