Title of article
Synthesis and Cytotoxic Activity of Novel 9-[Hydroxy(Substitutedphenyl) Methyl]-2,2-Dimethyl-2,3,8,9-Tetrahydro-4H,10H-Pyrano [2,3-f ]Chromene-4,10-Diones
Author/Authors
-، - نويسنده Iranian Research Institute of Plant Protection (IRIP), Tehran, I.R. IRAN Heidary Alizadeh, Babak , -، - نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, I.R. IRAN Vosooghi, Mohsen , -، - نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran, Tehran University of Medical Sciences, I.R. IRAN Khoobi, Mehdi , -، - نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran, Tehran University of Medical Sciences, I.R. IRAN Javidnia, Azita , -، - نويسنده Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384 Tehran, I.R. IRAN Panah,, Fatemeh , -، - نويسنده Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384 Tehran, I.R. IRAN Safavi, Maliheh , -، - نويسنده Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384 Tehran, I.R. IRAN Ardestani, Sussan , -، - نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran, Tehran University of Medical Sciences, I.R. IRAN Shafiee, Abass
Issue Information
فصلنامه با شماره پیاپی 56 سال 2010
Pages
8
From page
189
To page
196
Abstract
-
Abstract
Chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. Novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4H,10H-pyrano[2,3-f]chromene-4,10-diones as Glyasperin analogues were synthesized in four steps from known 4-chromone 1. The key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization reaction in 85% yield. Condensation of 5a with substituted aromatic aldehydes afforded corresponding alpha hydroxybenzyl analogues 6a-6e. The cytotoxic study of the synthesized compounds against breast cancer human cell line (T47D) showed moderate cytotoxic activities (IC50=16-40 μM) compared to the positive control drug vincristin (IC50=2.5 μM).
Journal title
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Serial Year
2010
Journal title
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Record number
2063024
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