Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Background: Clinical studies have shown that precipitation of urate crystals in joints of hyperuricemic patients could lead to systemic inflammation; however, this subject has been little explored in patients undergoing hemodialysis.. Objectives: We carried out this study in order to evaluate the association of serum uric acid (SUA) levels with plasma concentrations of CRP, an inflammatory marker, and ferritin in hemodialysis patients.. Materials and Methods: This cross-sectional study was conducted on 182 hemodialysis patients in two hemodialysis wards in Iran. Required laboratory parameters, including serum levels of uric acid, C-reactive protein, lipid profiles (cholesterol, triglyceride, HDL, LDL), and ferritin were measured. Demographic data were also collected with the self-report survey. P Value less than 0.05 is considered significant.. Results: Higher serum levels of uric acid and CRP were seen in 44% and 47% of the patients, respectively. Hyperferritinemia was observed in 80% of participants. Although there was a significant relationship between SUA level and plasma triglyceride (P = 0.007), a linear correlation indicated that SUA level had no significant association with CRP and ferritin.. Conclusions: Our results indicated that there is no statistical relationship between SUA level and CRP and serum ferritin. Detailed investigations with larger sample size are recommended.. Keywords: Renal Insufficiency; Chronic Kidney Failure; Renal Dialysis; Uric Acid; C-reactive Protein; Ferritin.