Title of article :
Effect of Gabapentin on Morphine Consumption and Pain after Surgical Debridement of Burn Wounds:A Double-Blind Randomized Clinical Trial Study
Author/Authors :
Rimaz، Siamak نويسنده Anesthesiology Research Center, Velayat University Hospital, Guilan University of Medical Sciences, Rasht, IR Iran Rimaz, Siamak , Emir Alavi، Cyrus نويسنده Anesthesiology Research Center, Velayat University Hospital, Guilan University of Medical Sciences, Rasht, IR Iran Emir Alavi, Cyrus , Sedighinejad، Abbas نويسنده استاديار بيهوشي، فلوشيپ بيهوشي قلب، دانشگاه علوم پزشكي گيلان، بيمارستان پورسينا، بخش بيهوشي صديقي نژاد, عباس , Tolouie، Mohammad نويسنده Department of Burn Surgery, Velayat University Hospital, Guilan University of Medical Sciences, Rasht, IR Iran Tolouie, Mohammad , Kavoosi، Sharareh نويسنده Department of Guilan Country Planning, Rasht, IR Iran Kavoosi, Sharareh , Koochakinejad، Leila نويسنده Department of Nursing, Velayat University Hospital, Rasht, IR Iran Koochakinejad, Leila
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2012
Abstract :
Burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. Uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. Although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. The anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. Experimental and clinical studies have demonstrated antihyperalgesic effects in models with central neuronal sensitization. It has been suggested that central neuronal sensitization may play an important role in postoperative pain. The aim of this study was to investigate the effect of gabapentin on morphine consumption and postoperative pain in burn patients undergoing resection of burn wounds. All the enrolled patients were able to complete the study; therefore, data from 50 patients wereanalyzed. The VAS scores at rest andduring movement at 1,4,8,12,16,20, and 24 h after the operation were significantly lower in the gabapentin group than in the placebo group (P < 0.05). Morphine consumption was significantly lessr in the gabapentin group than in the placebo group (P < 0.05). Sedation scores were similar in the 2 groups at all measured times. There were no differences in adverse effects between the groups. A single oral dose of 1200mg gabapentin resulted in a substantial reduction in postoperative morphine consumption and pain scores after surgical debridement in burn patients.
Abstract :
Burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. Uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. Although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. The anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. Experimental and clinical studies have demonstrated antihyperalgesic effects in models with central neuronal sensitization. It has been suggested that central neuronal sensitization may play an important role in postoperative pain. The aim of this study was to investigate the effect of gabapentin on morphine consumption and postoperative pain in burn patients undergoing resection of burn wounds. All the enrolled patients were able to complete the study; therefore, data from 50 patients wereanalyzed. The VAS scores at rest andduring movement at 1,4,8,12,16,20, and 24 h after the operation were significantly lower in the gabapentin group than in the placebo group (P < 0.05). Morphine consumption was significantly lessr in the gabapentin group than in the placebo group (P < 0.05). Sedation scores were similar in the 2 groups at all measured times. There were no differences in adverse effects between the groups. A single oral dose of 1200mg gabapentin resulted in a substantial reduction in postoperative morphine consumption and pain scores after surgical debridement in burn patients.
Journal title :
Archives of Trauma Research
Journal title :
Archives of Trauma Research