Title of article
Risk Factor Analysis Among Trimethoprim-Sulfamethoxazole Resistant Escherichia coli Isolates
Author/Authors
Masaeli، Milad نويسنده Student Research Committee, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran Masaeli, Milad , Faraji، Tayyebe نويسنده Student Research Committee, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran Faraji, Tayyebe , Ramazanzadeh، Rashid نويسنده Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran Ramazanzadeh, Rashid , Mansouri، Majid نويسنده Department of Pediatric, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran Mansouri, Majid
Issue Information
فصلنامه با شماره پیاپی 0 سال 2014
Pages
1
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Abstract
Trimethoprim-sulfamethoxazole (TMP-SMX) can be used for treatment of several infections including respiratory, renal, and gastrointestinal tract infections, skin and wound infections, septicaemia, and other infections caused by sensitive organisms. The aim of this study was to evaluate the risk factors for acquisition of TMP-SMX-resistant Escherichia coli strains among hospitalized patients in a university hospital of Sanandaj, Iran. It was a case-control study on a patient, carrying a TMP-SMX-resistant E. coli strain. The control patient carried a TMP-SMX-sensitive E. coli strain. TMP-SMX resistance was determined using disk diffusion methods. Of 343 isolates, 197 (57.43%) were TMP-SMX-resistant. Using ventilator and catheter were risky for acquisition of TMP-SMX-resistant isolate (odds ratio (OR) = 3.037, 95% CI = 1.60-5.75, P < 0.000; OR = 2.93, 95% CI = 1.15-7.43, P < 0.013, respectively). There was significant correlation between days of stay in ward and TMP-SMX resistance (P < 0.003). The main risk factors associated with TMP-SMX resistance were use of ventilator and catheter and days of stay in ward. There is need for more studies to evaluate the role of this factor to control the spread of drug resistance.
Abstract
Trimethoprim-sulfamethoxazole (TMP-SMX) can be used for treatment of several infections including respiratory, renal, and gastrointestinal tract infections, skin and wound infections, septicaemia, and other infections caused by sensitive organisms. The aim of this study was to evaluate the risk factors for acquisition of TMP-SMX-resistant Escherichia coli strains among hospitalized patients in a university hospital of Sanandaj, Iran. It was a case-control study on a patient, carrying a TMP-SMX-resistant E. coli strain. The control patient carried a TMP-SMX-sensitive E. coli strain. TMP-SMX resistance was determined using disk diffusion methods. Of 343 isolates, 197 (57.43%) were TMP-SMX-resistant. Using ventilator and catheter were risky for acquisition of TMP-SMX-resistant isolate (odds ratio (OR) = 3.037, 95% CI = 1.60-5.75, P < 0.000; OR = 2.93, 95% CI = 1.15-7.43, P < 0.013, respectively). There was significant correlation between days of stay in ward and TMP-SMX resistance (P < 0.003). The main risk factors associated with TMP-SMX resistance were use of ventilator and catheter and days of stay in ward. There is need for more studies to evaluate the role of this factor to control the spread of drug resistance.
Journal title
International Journal of Enteric Pathogens
Serial Year
2014
Journal title
International Journal of Enteric Pathogens
Record number
2068561
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