Title of article
Correlation between the level of cholesteryl ester transfer protein in follicular fluid with fertilization rates in IVF/ ICSI cycles
Author/Authors
Mehdizadeh، Amir Hossein نويسنده Department of Management, Islamic Azad University, South Tehran Branch, Tehran, Iran , , Rahimipour، Ali نويسنده Department of Laboratory Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Farzadi، Laya نويسنده Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Darabi، Masoud نويسنده Department of Biochemistry and Clinical Laboratories, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Shahnazi، Vahideh نويسنده , , Shaaker، Maghsod نويسنده Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Vatankhah، Amir-Mansour نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Golmohamadi، Zahra نويسنده 2 Laboratory of Chromatography, Department of Biochemistry and clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabr , , Nouri، Mohammad نويسنده 2 Laboratory of Chromatography, Department of Biochemistry and clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabr ,
Issue Information
فصلنامه با شماره پیاپی سال 2011
Pages
6
From page
193
To page
198
Abstract
Background: Follicular fluid (FF) plays an important role in oocytes and embryo development, which may contribute to IVF/ICSI success rate.
Objective: The aim of this study was to investigate the correlation between cholesteryl ester transfer protein (CETP) level in FF and the success rate of IVF/ICSI.
Materials and Methods: In a cross-sectional study, FF samples, FF samples were obtained from 100 patients referred to Tabriz Alzahra Hospital. Seventy-nine subjects underwent IVF and the remaining 21 underwent ICSI. The levels of high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I and CETP were measured using enzymatic, turbidometric and ELISA methods respectively.
Results: Analysis of the subgroups with different levels of CETP showed a significant lower level of CETP in the subgroup with the lowest number of mature oocytes (p < 0.05). The level of CETP was also considerably lower (18%, p=0.05) in subjects with < 50% oocytes fertilization ratio than subjects with > 70% of this ratio.
Conclusion: While no association was found for pregnancy, the amount of CETP in FF was associated positively to the maturity and the percentage of oocyte fertilization
Journal title
International Journal of Reproductive BioMedicine
Serial Year
2011
Journal title
International Journal of Reproductive BioMedicine
Record number
2068758
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