Author/Authors :
Mehdizadeh، Amir Hossein نويسنده Department of Management, Islamic Azad University, South Tehran Branch, Tehran, Iran , , Rahimipour، Ali نويسنده Department of Laboratory Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Farzadi، Laya نويسنده Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Darabi، Masoud نويسنده Department of Biochemistry and Clinical Laboratories, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Shahnazi، Vahideh نويسنده , , Shaaker، Maghsod نويسنده Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Vatankhah، Amir-Mansour نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Golmohamadi، Zahra نويسنده 2 Laboratory of Chromatography, Department of Biochemistry and clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabr , , Nouri، Mohammad نويسنده 2 Laboratory of Chromatography, Department of Biochemistry and clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabr ,
Abstract :
Background: Follicular fluid (FF) plays an important role in oocytes and embryo development, which may contribute to IVF/ICSI success rate.
Objective: The aim of this study was to investigate the correlation between cholesteryl ester transfer protein (CETP) level in FF and the success rate of IVF/ICSI.
Materials and Methods: In a cross-sectional study, FF samples, FF samples were obtained from 100 patients referred to Tabriz Alzahra Hospital. Seventy-nine subjects underwent IVF and the remaining 21 underwent ICSI. The levels of high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I and CETP were measured using enzymatic, turbidometric and ELISA methods respectively.
Results: Analysis of the subgroups with different levels of CETP showed a significant lower level of CETP in the subgroup with the lowest number of mature oocytes (p < 0.05). The level of CETP was also considerably lower (18%, p=0.05) in subjects with < 50% oocytes fertilization ratio than subjects with > 70% of this ratio.
Conclusion: While no association was found for pregnancy, the amount of CETP in FF was associated positively to the maturity and the percentage of oocyte fertilization
