Culture of mammalian cells on polypyrrole-coated ITO as a biocompatible electrode

Primary culture of the chromaffin cells on polypyrrole-coated indium-tin oxide was performed and the influence of polypyrroles having some kinds of dopants on cell function was investigated. While the cells cultured on indium-tin oxide showed decrease of catecholamine release, those on polypyrrole-coated indium-tin oxide maintained the cell function of release of catecholamines. Furthermore, no influence of various dopants on the secretory function from the cultured cells was observed. To prepare polypyrrole on electrode as a cell-culture substrate was considered to be available for supporting the cell function.