Polymeric molluscicides containing niclosamide moieties

Polymeric molluscicides containing a niclosamide moiety have been prepared by the chemical reactions of the commercial resins: poly(methacrylic acid),poly(styrene sulfonic acid),poly(chloromethylstyrene), poly (vinylbenzyltrimethylammonium chloride) with niclosamide. The resulting polymers contain the niclosamide active group via a covalent or ionic bond. lease rates of niclosamide were determined in different pH media by UV spectrophotometric analyses. The data of the niclosamide release from the different polymeric systems show that the pH of the medium, the type of linkage between the polymer and the active moiety, and the degree of crosslinking present in the polymer are important factors governing the release rates.