Protein adsorption on self-assembled monolayers with water-soluble non-ionic oligomers using quartz-crystal microbalance

This study was conducted to determine protein adsorption characteristics on water-soluble non-ionic oligomers. Oligomers of ethylene glycol (Oligo-EG), acrylamide (Oligo-AM) and N,N-dimethylacrylamide (Oligo-DMA) were coupled to 12-mercaptododecanoic acid. Self-assembled monolayers (SAMs) of these alkanethiols were formed on gold electrodes of quartz-crystal microbalance (QCM). The protein adsorption on SAMs, determined using QCM technique, was decreased in order: Oligo-EG<Oligo-AM-<Oligo-DMA.