Lanthanide recognition: A Ho3+ potentiometric membrane sensor as a probe for determination of terazosin

In this study, complexation of N′-(1-pyridin-2-ylmethylene)-2-furohydrazide (NFH) with some metal ions was investigated by conductometry and spectroscopy. Then, a Ho3+ potentiometric membrane sensor was prepared based on the highly selective complexation between this ionophore and Ho3+. These new ionophores are more selective than the previously reported ones. In this work, for the first time, the proposed sensor was applied in indirect determination of the terazocine in its pharmaceutical formulation. The interest in constructing lanthanide sensors arises because they have similar ionic radii to calcium, but a higher charge density, which allows them to be used as probes to find the interactions between Ca2+ and biologically important molecules.