Title of article
Attenuated effects of chitosan-capped gold nanoparticles on LPS-induced toxicity in laboratory rats
Author/Authors
Stefan، نويسنده , , Marius and Melnig، نويسنده , , Viorel and Pricop، نويسنده , , Daniela and Neagu، نويسنده , , Anca and Mihasan، نويسنده , , Marius and Tartau، نويسنده , , Liliana and Hritcu، نويسنده , , Lucian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
7
From page
550
To page
556
Abstract
The impact of nanoparticles in medicine and biology has increased rapidly in recent years. Gold nanoparticles (AuNP) have advantageous properties such as chemical stability, high electron density and affinity to biomolecules. However, the effects of AuNP on human body after repeated administration are still unclear. Therefore, the purpose of the present study was to evaluate the effects of gold-11.68 nm (AuNP1, 9.8 μg) and gold-22.22 nm (AuNP2, 19.7 μg) nanoparticles capped with chitosan on brain and liver tissue reactivity in male Wistar rats exposed to lipopolysaccharide (LPS from Escherichia coli serotype 0111:B4, 250 μg) upon 8 daily sessions of intraperitoneal administration. Our results suggest that the smaller size of chitosan-capped AuNP shows the protective effects against LPS-induced toxicity, suggesting a very high potential for biomedical applications.
Keywords
TOXICITY , Chitosan , Gold nanoparticles , Lipopolysaccharide
Journal title
Materials Science and Engineering C
Serial Year
2013
Journal title
Materials Science and Engineering C
Record number
2102541
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