Susceptibility of juvenile and sub-adult Atlantic halibut (Hippoglossus hippoglossusL.) to infection byVibrio anguillarumand efficacy of protection induced by vaccination

Experimental bath challenge of juvenile and sub-adult Atlantic halibut with Vibrio anguillarum induced severe mortalities of 47 and 80%, respectively. However, animals vaccinated with a commercial V. anguillarum vaccine demonstrated excellent protection against the disease (100% RPS). This study also describes the gross pathology and histological changes associated with this infection. A loss of coordination, haemorrhage at the fin base and splenomegaly were frequent findings. agglutinating activity demonstrated a rise following vaccination, the mean log2titre rising from 3·8 to 8·4. This was associated with a significant rise in antibody-mediated complement killing ability of immune serum when compared to non-immune serum. \