Title of article
Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus
Author/Authors
Prado-Alvarez، نويسنده , , M. and Rotllant، نويسنده , , J. van Gestal، نويسنده , , C. and Novoa، نويسنده , , B. and Figueras، نويسنده , , A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
11
From page
305
To page
315
Abstract
The alternative pathway is considered to be the most ancient route for activation of the complement system. Herein, we report the characterization of C3 and factor B-like proteins in the clam Ruditapes decussatus, termed Rd-C3 and Rd-Bf-like. The Rd-C3 is a three-chain protein, similar to other protoC3 proteins, and the Rd-Bf-like is composed of two complement control protein modules (CCP domains) that differ from other described Bf proteins. The inoculation of clams with live bacteria did not result in induction of these functions, but inhibited the expression of Rd-C3 and Rd-Bf-like.
Keywords
Gene expression , Clam , Ruditapes decussatus , complement , C3 , factor B
Journal title
Fish and Shellfish Immunology
Serial Year
2009
Journal title
Fish and Shellfish Immunology
Record number
2108409
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