Title of article :
Anti-viral activity of galectin-1 from flounder Paralichthys olivaceus
Author/Authors :
Liu، نويسنده , , Shousheng and Hu، نويسنده , , Guobin and Sun، نويسنده , , Chen and Zhang، نويسنده , , Shicui، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
Galectins are a family of Ca2+-independent soluble lectins characterized by their affinity to β-galactosides. Mammalian galectins have been shown to play a defense role against certain bacteria, fungi and viruses. However, the immunological functions of galectins in fish is poorly characterized. Here we demonstrated that the expression of galectin-1 gene from the flounder Paralichthys olivaceus was decreased in the initial 8 h after challenge with poly I:C, then increased markedly from 24 h onwards, and the recombinant galectin-1 was able to neutralize the lymphocystis disease virus (LCDV), inhibiting the formation of cytopathic effects. In addition, the recombinant galectin had a potential anti-inflammatory activity against infection by LCDV, and was able to restrain the overexpression of the anti-viral protein gene mx against virus infection. These results indicate that flounder galectin-1 has an anti-viral activity, capable of reducing LCDV pathogenicity.
Keywords :
Galectin-1 , flounder , innate immunity , Anti-viral activity
Journal title :
Fish and Shellfish Immunology
Journal title :
Fish and Shellfish Immunology