Title of article :
Safety evaluation of a natural eggshell membrane-derived product
Author/Authors :
Ruff، نويسنده , , Kevin J. and Endres، نويسنده , , John R. and Clewell، نويسنده , , Amy E. and Szabo، نويسنده , , James R. and Schauss، نويسنده , , Alexander G.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
8
From page :
604
To page :
611
Abstract :
Natural Eggshell Membrane (NEM®) is a novel dietary ingredient that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joint and connective tissues. NEM® was evaluated for safety via in vitro and in vivo toxicological studies. This included testing for cytotoxicity, genotoxicity, acute oral toxicity, and 90-day repeated-dose oral toxicity. NEM® did not exhibit any cytotoxic effects at a dose of 100 μg in an in vitro human cell viability assay after incubation for up to 20 h. NEM® did not exhibit any genotoxic effects in an in vitro assay of four strains of histidine-dependent Salmonella typhimurium and one strain of tryptophan-dependent Escherichia coli at a dose of up to 5000 μg/plate. NEM® did not exhibit any signs of acute toxicity in rats at a single oral dose of up to 2000 mg/kg body weight, nor signs of toxicity (via urinalysis, hematology, clinical chemistry, or histopathological evaluation) in rats at a repeated oral dose of up to 2000 mg/kg body weight per day for 90 days. The results of these studies suggest that NEM® may be safe for human consumption.
Keywords :
Eggshell membrane , Safety , TOXICITY , glycosaminoglycan
Journal title :
Food and Chemical Toxicology
Serial Year :
2012
Journal title :
Food and Chemical Toxicology
Record number :
2114707
Link To Document :
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