Title of article :
Prolonged oral treatment with an essential amino acid l-leucine does not affect female reproductive function and embryo-fetal development in rats
Author/Authors :
Mawatari، نويسنده , , Kazunori and Katsumata، نويسنده , , Toyohisa and Uematsu، نويسنده , , Masanobu and Katsumata، نويسنده , , Tomoyoshi and Yoshida، نويسنده , , Junichi and Smriga، نويسنده , , Miro and Kimura، نويسنده , , Takeshi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
7
From page :
1505
To page :
1511
Abstract :
l-leucine, an essential amino acid, is one of the most popular ingredients in dietary supplements. To investigate a possibility of its embryo-fetal toxicity in rats, 11- to 12-week old dams were orally administered an aqueous solution of l-leucine at doses of 300 or 1000 mg/kg body weight on gestational days 7–17. Body weight and feed intake was evaluated throughout the whole course of pregnancy (days 0–20). l-Leucine did not influence body weight, but at a dose of 1000 mg/kg, slightly enhanced feed intake on days 14 and 18 of pregnancy. Caesarean section (day 20) revealed no influences on the litter size and weight of live-born fetuses, the number of corpora lutea, implantation index or the quality of placenta, and the minor increase in feed intake was considered irrelevant to the pregnancy outcomes. Fetuses were evaluated in a battery of external, visceral and skeletal examinations. No effects of l-leucine on gender ratio and external abnormalities, and no significant treatment-related variations in visceral and skeletal pathologies were observed. These results suggested that l-leucine, administered orally during organogenesis at doses up to 1000 mg/kg body weight, did not affect the outcome of pregnancy and did not cause fetotoxicity in rats.
Keywords :
Fetus , Pregnancy , L-leucine , Rat , Fetal Development
Journal title :
Food and Chemical Toxicology
Serial Year :
2004
Journal title :
Food and Chemical Toxicology
Record number :
2118020
Link To Document :
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